Progesterone in Oil is an injectable medication for women that contains a naturally occurring hormone called progesterone. Progesterone is commonly referred to as the “pregnancy hormone” because it is essential in helping the uterus prepare for and maintain a healthy pregnancy. During fertility treatment such as IVF, medications used to prevent premature ovulation (Cetrotide®, Ganirelix Acetate, or Lupron®) can suppress your body’s ability to produce its own progesterone. As a result, supplementation with progesterone may be needed. Progesterone in Oil is prescribed to women to prepare the uterine lining to receive an embryo (fertilized egg) and prevent a miscarriage after the embryo implants. During IVF, Progesterone in Oil is typically taken as a daily intramuscular (into the muscle) injection at the time of egg retrieval and continued for up to 12 weeks to support an ongoing pregnancy.
Progesterone in Oil comes in a premixed 50mg/mL multiple dose vial or in a “double-strength” 100mg/mL multiple dose vial that is compounded by the pharmacy.
- Progesterone in Oil 50mg/mL Vial
- Progesterone in Oil 100mg/mL Vial (Compound)
Common side effects of Progesterone in Oil include:
- Pain, bruising, swelling, or redness at the injection site
- Breast tenderness
- Headache
- Weight gain or loss
- Acne
- Nausea
- Increased body or facial hair
- Loss of scalp hair
- Drowsiness
- Dizziness
Contact your doctor immediately if you experience any of the following rare but serious side effects, including:
- Symptoms of a severe allergic reaction such as: sense of uneasiness or apprehension, flushing, fast/throbbing heartbeat, itching, hives, difficult breathing, swelling of the throat, fainting, nausea, vomiting, or convulsions.
- Symptoms of a blood clot such as: chest, jaw, or left arm pain, weakness on one side of the body, trouble speaking, vision changes, confusion, pain/redness/swelling of the arms or legs, trouble breathing, sudden severe headache, or fainting
- Unusual vaginal bleeding or discharge (such as breakthrough bleeding or spotting)
- Stopped menstrual periods
- Breast lumps
- Swelling of the ankles or feet
- Mental or mood changes (such as depression or nervousness)
- Dark patches on the skin or face
- Frequent or painful urination
- Dark urine
- Yellow eyes or skin
- Stomach or abdominal pain
- Persistent nausea or vomiting
This is not a complete list of side effects that may occur. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Progesterone in Oil should be stored at room temperature (68℉ to 77℉). Do not refrigerate.
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