Low-dose hCG, also called micro-dose hCG, is an injectable medication containing a hormone called human chorionic gonadotropin (hCG) that is prescribed to women undergoing fertility treatment. Because hCG is similar in structure to luteinizing hormone (LH) which plays a critical role in egg development and maturity, a low-dose of hCG may be prescribed by your doctor to mimic the positive effects of LH during ovarian stimulation. Low-dose hCG is compounded in the pharmacy by taking a full-strength vial of manufactured hCG (Novarel® or Pregnyl®) and diluting it down to a much lower strength. Low-dose hCG is taken as a daily subcutaneous (under the skin) injection for approximately 8-12 days to supplement stimulation with an FSH medication (Follistim AQ® or Gonal-f®). Do not confuse low-dose hCG with your hCG trigger shot (Pregnyl®). While both products contain the same medication, their respective uses are very different.
Low-dose hCG is a sterile compound that comes in a premixed 10mL multiple dose vial containing 100 units/mL of hCG, along with a 100 unit insulin syringe for injection.
- Low-dose hCG 100 units/mL Vial (Compound)
Common side effects of hCG include:
- Headaches
- Feeling restless or irritable
- Depression
- Fatigue
- Fluid retention (edema)
- Pain at the injection site
- Breast tenderness or swelling
Some women using hCG develop ovarian hyperstimulation syndrome (OHSS) during or shortly after treatment. OHSS can be life threatening. Call your doctor right away if you experience any of the symptoms of OHSS including: severe pelvic pain, abdominal pain and bloating, shortness of breath, rapid weight gain, decreased urination, diarrhea, nausea, or vomiting.
Contact your doctor immediately if you experience any of the following rare but serious side effects, including:
- Severe allergic reaction, including anaphylaxis: Rash, swelling of the face, lips, tongue, or throat, severe dizziness, or trouble breathing.
- Lung problems: Fluid in your lungs, blue lips/fingernails/skin, chest tightness, coughing, difficulty breathing, fever, rapid heartbeat
- Blood clots: Pain, swelling or warmth in the leg, shortness of breath, chest pain
- Heart attack: Chest pain or tightness, pain that radiates up your shoulder, arm, neck, or jaw
- Stroke: Sudden problems with vision, speech, or walking, numbness on one side of your body or face
- Early puberty in boys: Enlarged testicles and penis, facial hair, deepened voice, acne, rapid increase in height
This is not a complete list of side effects that may occur. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Low-dose hCG should be stored refrigerated (36℉ to 46℉). Once punctured, the vial can be stored refrigerated for up to 28 days. Do not freeze. Protect from light. Do not use after the beyond use date listed on the medication.
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