The Lupron® Trigger (Leuprolide Trigger) is a subcutaneous (under the skin) injection of Leuprolide Acetate that is taken during IVF to induce the final maturation of the eggs prior to egg retrieval. It is typically administered approximately 36 hours prior to egg retrieval to produce a surge of luteinizing hormone (LH) that mimics the natural surge of LH that the body experiences during ovulation. The Lupron® Trigger is prescribed as an alternative to triggering with human chorionic gonadotropin (hCG) because it is less likely to cause a serious side effect called Ovarian Hyperstimulation Syndrome (OHSS). Do not confuse the Lupron® Trigger with the Lupron®14 Day Kit. While both products contain the same medication, their respective uses are very different.
The Lupron® Trigger is a sterile compound that comes in a prefilled syringe or a prefilled vial. The ready-to-use prefilled syringe contains 4mg/0.8 mL and requires no mixing or drawing up of medication. The prefilled vial comes in two preparations containing 4 mg/0.8 mL or 5 mg/mL which must be drawn up with a syringe before injection.
- Lupron® Trigger 4mg/0.8 mL Prefilled Syringe (Compound)
- Lupron® Trigger 4mg/0.8 mL Vial (Compound)
- Lupron® Trigger 5mg/mL Vial (Compound)
Common side effects of Lupron® (Leuprolide Acetate) include:
- Pain, bruising, swelling, or redness at the injection site
- Hot flashes
- Sweating
- Tiredness
- Headache
- Upset stomach
- Breast changes
- Acne
- Joint/muscle aches
- Insomnia
- Decreased libido
- Vaginal dryness, discomfort, or bleeding
- Swelling of the ankles or feet
- Increased urination at night
- Dizziness
- Symptoms of a severe allergic reaction such as: swelling of the face, lips, tongue, or throat, severe dizziness, or trouble breathing
- Bone pain
- Easily broken bones
- Increased thirst or urination
- Mood changes such as depression or thoughts of suicide
- Symptoms of a heart attack such as: chest, jaw, or left arm pain, shortness of breath, or unusual sweating
- Symptoms of a stroke such as: weakness on one side of the body, slurred speech, sudden vision changes, or confusion
- Irregular heart beat
- Severe dizziness
- Fainting
- Seizures
This is not a complete list of side effects that may occur. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
The Lupron Trigger® should be stored refrigerated (36℉ to 46℉). Do not freeze. Protect from light. Do not use after the beyond use date listed on the medication.
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